Zhu Y, Xu Y, Helseth L, et al., Ji Y*. Zodiac: A Comprehensive Depiction of Genetic Interactions in Cancer by Integrating TCGA Data. Journal of the National Cancer Institute. 107(8): div129 doi:10.1093/jnci/djv129, 2015
Zodiac, like Google, is a search engine. You type queries in the search bar above, and Zodiac subsequently returns search results. We advise that you read the tutorial above, or continue reading below.
Unlike the almighty Google, Zodiac is small. And unlike Google, which allow searches for pretty much anything, Zodiac provides results for only one type of search, i.e., genetic interactions in cancer.
So what can you "Zodiac"?
You can "Zodiac" any genes names. You can input one, two, or more gene names in the search bar, and Zodiac returns networks of genes with multiple features such as copy number, gene expression, methylation, and some protein expression, along with mutation and microRNA in the near future.
So what makes Zodiac different from other network databases?
- Zodiac is novel. All the interactions in Zodiac are produced based on statistical inference utilizing data from The Cancer Genome Atlas (TCGA).
- Zodiac is an evolution of our knowledge about genetic interactions in cancer by treating pre-existing knowledge (such as a KEGG pathway) as a prior graph, integrating it with a likelihood model for TCGA data, and producing a posterior graph representing updated and data-enhanced knowledge. In short, Zodiac realizes the following:
- Zodiac is massive and growing. It contains about 200 million networks for all the gene pairs genome-wide.
- Zodiac is useful. It provides false discovery rates on the genetic interactions, and ranks genetic interactions based on posterior probabilities.
Prior network + TCGA data —> Posterior network
- Zodiac helps you understand how genes interact in cancer conditions. The networks contained in Zodiac are based on rigorous statistical inference utilizing prior knowledge and TCGA data.
- Zodiac helps discover interacting gene, and consequently, potential drug targets.
- Zodiac identifies potential genetic aberrations such as gene fusions.
- Zodiac is easy to use and allows for real-time look-up of genetic interactions while reading a paper, listening to a seminar, or browsing the internet.
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